Now Caroline Reynolds has stepped down as president, she can no longer sign a pardon, so the brothers must immediately disappear, forever. At the pier, Sarah realizes she's being tailed and pretends on the phone already to be on board, so they sail without her while she is arrested; Lincoln stops Michael from returning for her. A week later, an FBI big-whig offers C-note a lesser sentence for testimony against Mahone, even freedom and witness protection for his family- bingo. Fernando grabs Bellick's gun while looking for T-bag, but he shows a crucifix to prove he has Maricruz. The scumbag enjoys his fortune with a street whore playing his Susan-Q.
The brothers arrive at Cristobal, Panama; meanwhile Malone's team figures out Schofield's tattoos refer to Michael's mother Christina, presumably dead, and he presumes his computer contained much info on Panama for a reason. The man in power grills Kim on a small boat, and decides to change the strategy. Mahone sees trough FBI-colleague Wheeler. C-note is reunited with his family and released. The brothers have a fight, torn by guilt for too many innocent people suffering trough their well-meant deeds, then board a yacht, named- Christina. Mahone tells Kim he's not happy with the results as he remains separated from his family, but is told he now needs help to escape, and therefore must go to Mexico- to help T-bag... [last bit not summarized].